(2-(tert-Butyl)thiazol-4-yl)methanamine → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide

HRID 1026057Notes

Reaction equation

HRID 1026057 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:4][CH:3]=1.[CH3:22][C:23]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH2:32])[N:30]=1)([CH3:25])[CH3:24]>>[C:23]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH:32][C:14]([C:12]2[CH:11]=[CH:10][C:9]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[N:30]=1)([CH3:25])([CH3:22])[CH3:24]

Participants

3

Reactant 2

HCID 16494974(2-(tert-Butyl)thiazol-4-yl)methanamineHCID 666786056-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 569290066-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAN 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 97.7%, 456.0 (M+H)+.

Sources & evidence

ORD record
ord-e7d66bb8bb0b4423a7bf7ce85f467691
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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