HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamine → (S)-4-(4-chlorophenyl)-N-((3-(trifluoromethyl)isoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrimidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamine | HCID 54405670 | — |
| Reactant | (S)-4-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrimidine-2-carboxylic acid | HCID 66678696 | — |
| Product | (S)-4-(4-chlorophenyl)-N-((3-(trifluoromethyl)isoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrimidine-2-carboxamide | HCID 56929100 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using (S)-4-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrimidine-2-carboxylic acid (example AQ) and 3-trifluoromethyl-isoxazol-5-methanamine (example BA) as starting materials; LC-MS (UV peak area/ESI) 100%, 495.0965 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-dae4d0822689488a8693eb52089c922e |
| Source note | uspto-grants-2014_05 |