2-Pyridinemethanamine → (S)-6-(4-chlorophenyl)-N-(pyridin-2-ylmethyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide

HRID 1026062Notes

Reaction equation

HRID 1026062 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[N:10][C:9]=2[O:17][C@@H:18]([CH3:23])[C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[CH2:30][NH2:31]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([NH:31][CH2:30][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=3)=[O:16])[CH:11]=[N:10][C:9]=2[O:17][C@@H:18]([CH3:23])[C:19]([F:21])([F:20])[F:22])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 195092-PyridinemethanamineHCID 66678820(S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid

Product 1

HCID 56929101(S)-6-(4-chlorophenyl)-N-(pyridin-2-ylmethyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxamide

Procedure

The title compound was synthesized in analogy to Example 1 using (S)-6-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)pyrazine-2-carboxylic acid (example AH) and 2-pyridinemethanamine (CAN 3731-51-9) as starting materials; MS (ESI): 437.1 (M+H)+.

Sources & evidence

ORD record
ord-51a0dc011c2c415a92ba15fabd501dc4
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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