3-Methoxy-5-isoxazolemethanamine → 4-(4-chloro-3-methylphenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

HRID 1026067Notes

Reaction equation

HRID 1026067 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][C:3]=1[CH3:23].[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:12][N:11]=[C:10]([C:20]([NH:32][CH2:31][C:29]3[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=3)=[O:22])[CH:9]=2)=[CH:4][C:3]=1[CH3:23]

Participants

3

Reactant 2

HCID 27632273-Methoxy-5-isoxazolemethanamineHCID 666787904-(4-Chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid

Product 1

HCID 569291874-(4-chloro-3-methylphenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid (example BN) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 100%, 456.0938 (M+H)+.

Sources & evidence

ORD record
ord-a1de49ca49704cb28cc0edbcf3d9f469
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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