(2-Cyclopropylthiazol-4-yl)methanamine → 4-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	(2-Cyclopropylthiazol-4-yl)methanamine	HCID 45792629	—
Reactant	4-(4-Chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid	HCID 66678790	—
Product	4-(4-chloro-3-methylphenyl)-N-((2-cyclopropylthiazol-4-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide	HCID 56929275	—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid (example BN) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9) as starting materials; LC-MS (UV peak area/ESI) 100%, 482.0911 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-f501496bce0444b59ffd2cc165ee3bed
Source note	uspto-grants-2014_05