(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine	HCID 55263061	—
Reactant	4-(4-Chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid	HCID 66678790	—
Product	4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide	HCID 56929276	—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 4-(4-chloro-3-methylphenyl)-5-(2,2,2-trifluoroethoxy)picolinic acid (example BN) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 100%, 493.0499 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-66eee89c931a447aa95d975a93acc6e4
Source note	uspto-grants-2014_05