HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,3-dihydro-1H-inden-5-yl)boronic acid → 5-(2,3-dihydro-1H-inden-5-yl)-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,3-dihydro-1H-inden-5-yl)boronic acid | HCID 22240187 | — |
| Reactant | 5-bromo-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide | HCID 86663143 | — |
| Product | 5-(2,3-dihydro-1H-inden-5-yl)-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide | HCID 56929373 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 83 using 5-bromo-6-(2,2,2-trifluoroethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide (example BP) and B-(2,3-dihydro-1H-inden-5-yl)-boronic acid (CAN 196861-31-1) as starting materials; LC-MS (UV peak area/ESI) 100%, 485.1016 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-be535ab0b3e5465697d08c5ad4016cd9 |
| Source note | uspto-grants-2014_05 |