3-Methoxy-5-isoxazolemethanamine → 5-(4-chloro-3-fluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

HRID 1026078Notes

Reaction equation

HRID 1026078 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][C:3]=1[F:23].[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:21])([F:20])[F:22])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:32][CH2:31][C:29]2[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=2)=[O:15])=[CH:4][C:3]=1[F:23]

Participants

3

Reactant 2

HCID 27632273-Methoxy-5-isoxazolemethanamineHCID 666786125-(4-Chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 569293745-(4-chloro-3-fluorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid (example BR) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) as starting materials; LC-MS (UV peak area/ESI) 100%, 458.0537 (M−H)−.

Sources & evidence

ORD record
ord-13949e412fb642e28eac0849a70e5472
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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