HCID 66678705, compound → HCID 56929461, compound

HRID 1026080Notes

Reaction equation

HRID 1026080 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH:23]1([CH2:26][N:27]2[CH:31]=[CH:30][C:29]([CH2:32][NH2:33])=[N:28]2)[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:20])([F:21])[F:22])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:33][CH2:32][C:29]2[CH:30]=[CH:31][N:27]([CH2:26][CH:23]3[CH2:25][CH2:24]3)[N:28]=2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 66678705HCID 66678705, compoundHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 56929461HCID 56929461, compound

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAN 1018782-82-5) and (1-(cyclopropylmethyl)-1H-pyrazol-3-yl)methanamine (example BW) as starting materials, MS (EI) 465.3 (M+H)+.

Sources & evidence

ORD record
ord-2a874e581e4a492e9e85e630b4c282e4
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

Loading…