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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026084Generated: October 31, 2026

(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 5-(4-chlorophenyl)-6-cyclobutoxy-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

https://huagongshe.com/reaction/1026084

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 55263061—
Reactant5-(4-Chlorophenyl)-6-cyclobutoxy-nicotinic acidHCID 66678618—
Product5-(4-chlorophenyl)-6-cyclobutoxy-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamideHCID 66678818—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 5-(4-chlorophenyl)-6-cyclobutoxy-nicotinic acid (example CA) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 92.8%, 451.1 (M−H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-db51d54fb74c470ab747e94617827a30
Source noteuspto-grants-2014_05