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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026087Generated: October 30, 2026

(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → 6-(cyclopropylmethoxy)-5-(3,4-difluorophenyl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

https://huagongshe.com/reaction/1026087

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 55263061—
Reactant6-(Cyclopropylmethoxy)-5-(3,4-difluorophenyl)nicotinic acidHCID 66678619—
Product6-(cyclopropylmethoxy)-5-(3,4-difluorophenyl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamideHCID 56929466—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using 6-(cyclopropylmethoxy)-5-(3,4-difluorophenyl)-nicotinic acid (example CD) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 100.0%, 455.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-1f174160b5e44386989b119dd5d8736e
Source noteuspto-grants-2014_05