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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026095Generated: October 31, 2026

(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → (R)-5-(4-chlorophenyl)-6-(tetrahydrofuran-3-yloxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide

https://huagongshe.com/reaction/1026095

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamineHCID 55263061—
Reactant(R)-5-(4-chlorophenyl)-6-(tetrahydrofuran-3-yloxy)nicotinic acidHCID 66678800—
Product(R)-5-(4-chlorophenyl)-6-(tetrahydrofuran-3-yloxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamideHCID 56929661—

Reaction Steps

The title compound was synthesized in analogy to Example 1 using (R)-5-(4-chlorophenyl)-6-(tetrahydrofuran-3-yloxy)nicotinic acid (example CJ) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; LC-MS (UV peak area/ESI) 94.6%, 469.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-80089222a80241c193edd5ed6e3aab74
Source noteuspto-grants-2014_05