HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine → (SR)-5-(4-chlorophenyl)-6-((tetrahydrofuran-3-yl)methoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-(Trifluoromethyl)-1,2,4-oxadiazol-5-YL)methanamine | HCID 55263061 | — |
| Reactant | 5-(4-Chloro-phenyl)-6-(tetrahydro-furan-3-ylmethoxy)-nicotinic acid | HCID 66678490 | — |
| Product | (SR)-5-(4-chlorophenyl)-6-((tetrahydrofuran-3-yl)methoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)nicotinamide | HCID 66687152 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-phenyl)-6-(tetrahydro-furan-3-ylmethoxy)-nicotinic acid (example CK) and 3-trifluoromethyl-[1,2,4]oxadiazol-5-methanamine (example AK) as starting materials; enantiomers were separated by chiral HPLC (ChiralPak AD, 30% ethanol/n-heptane (−) enantiomer isolated; LC-MS (UV peak area/ESI) 100%, 483.1038 (M+H)+; αD20(MeOH)=−12.2°
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c5dbefa86dbb44c180f9d931695ad15d |
| Source note | uspto-grants-2014_05 |