Cyanogen Bromide → HCID 45101104, compound

HRID 1026151Notes

Reaction equation

HRID 1026151 reaction equation
[NH2:1][C@@H:2]([CH2:5][CH2:6][CH:7]([C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)[CH2:8][CH3:9])[CH2:3][OH:4].[N:18]#[C:19]Br>>[F:17][C:12]1[CH:11]=[C:10]([CH:7]([CH2:8][CH3:9])[CH2:6][CH2:5][C@H:2]2[CH2:3][O:4][C:19]([NH2:18])=[N:1]2)[CH:15]=[C:14]([F:16])[CH:13]=1

Participants

3

Reactant 2

HCID 10476Cyanogen BromideHCID 67228627HCID 67228627, compound

Product 1

HCID 45101104HCID 45101104, compound

Procedure

In analogy to example 1d (S)-2-amino-5-(3,5-difluoro-phenyl)-heptan-1-ol was reacted with cyanogen bromide to give (4S)-4-[3-(3,5-difluoro-phenyl)-pentyl]-4,5-dihydro-oxazol-2-ylamine. Light yellow liquid. MS (ISP): 269.3 ([M+H]+).

Sources & evidence

ORD record
ord-d891f74c0289407cb7c8bd49cfacc58e
Source dataset
uspto-grants-2014_05
Patent number
US08729113B2

Reaction notes

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