Formaldehyde → HCID 22065274, compound

Participants

Reaction Steps

A mixture of Compound V (10.0 g, 31.6 mmol), paraformaldehyde (6.4 g), dimethylamine hydrochloride (9.4 g, 115 mmol) and sodium carbonate (13.3 g, 125 mmol) was dissolved in tetrahydrofuran (150 mL) and heated under reflux for 16 h. The reaction was cooled to room temperature, filtered and the filtrate was concentrated under reduced pressure to give a brown oil. Purification by column chromatography on silica gel 60, eluting with hexane/ethyl acetate (2:1 to 1:1) afforded Compound IV (5.3 g, 16 mmol, 51%) as a yellow oil.

Provenance & Evidence