Methylparaben → HCID 67777625, compound

Participants

Reaction Steps

To a solution of methyl 4-hydroxybenzoate (4.77 g), tert-butyl [(1S)-2-hydroxy-1-methylethyl]carbamate (5.00 g) and triphenylphosphine (11.2 g) in THF (70 mL) was added dropwise a toluene solution (2.2 M, 20 mL) of diethyl azodicarboxylate, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate). Using the obtained residue, and in the same manner as in Example 1, step D, the title compound (3.80 g) was obtained.

Provenance & Evidence