4-Aminobenzene-1,3-diol hydrochloride → 4-{[(2S)-2-(acetylamino)propyl]oxy}-N-(2,4-dihydroxyphenyl)benzamide

HRID 1026214Notes

Reaction equation

HRID 1026214 reaction equation
[C:1]([NH:4][C@@H:5]([CH3:17])[CH2:6][O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1)(=[O:3])[CH3:2].Cl.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][C:21]=1[OH:27]>>[C:1]([NH:4][C@@H:5]([CH3:17])[CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([C:12]([NH:19][C:20]2[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][C:21]=2[OH:27])=[O:14])=[CH:15][CH:16]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 134088224-Aminobenzene-1,3-diol hydrochlorideHCID 677786634-{[(2S)-2-(acetylamino)propyl]oxy}benzoic acid

Product 1

HCID 677777224-{[(2S)-2-(acetylamino)propyl]oxy}-N-(2,4-dihydroxyphenyl)benzamide

Procedure

Using 4-{[(2S)-2-(acetylamino)propyl]oxy}benzoic acid and 4-aminobenzene-1,3-diol hydrochloride, and in the same manner as in Example 2, step C, the title compound was obtained.

Sources & evidence

ORD record
ord-49b53a8209664ca08f4c0118fa7e0802
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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