Triphenylphosphine → HCID 86666273, compound

Participants

Reaction Steps

A toluene solution (1.9 M, 0.474 mL) of diisopropyl azodicarboxylate was added dropwise to a solution of tert-butyl [(1S)-2-hydroxy-1-methylethyl]carbamate (158 mg), triphenylphosphine (236 mg) and 6-[6-(cyclopropylmethoxy)-2,3-dihydro-1-benzofuran-2-yl]pyridin-3-ol (170 mg) in THF (30 mL) at room temperature. The reaction mixture was stirred at room temperature for 16 hr, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (80 mg).

Provenance & Evidence