HCID 84665874, compound → HCID 86666277, compound

HRID 1026253Notes

Reaction equation

HRID 1026253 reaction equation
[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[C:6]([N+:12]([O-])=O)[CH:5]=1)[CH3:2].[NH2:15][C:16]1[CH:33]=[CH:32][C:19]([O:20][CH2:21][C@@H:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])[CH3:23])=[CH:18][CH:17]=1>>[CH2:1]([O:3][C:4]1[CH:11]=[CH:10][C:7]2[C:6]([CH:5]=1)=[N:12][N:15]([C:16]1[CH:17]=[CH:18][C:19]([O:20][CH2:21][C@@H:22]([NH:24][C:25](=[O:31])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH3:23])=[CH:32][CH:33]=1)[CH:8]=2)[CH3:2]

Participants

3

Reactant 2

HCID 84665874HCID 84665874, compoundHCID 86666278HCID 86666278, compound

Product 1

HCID 86666277HCID 86666277, compound

Procedure

Using 4-ethoxy-2-nitrobenzaldehyde (293 mg) and tert-butyl [(1S)-2-(4-aminophenoxy)-1-methylethyl]carbamate (399 mg), and in the same manner as in Example 25, step F, the title compound was obtained as a pale-brown solid (459 mg).

Sources & evidence

ORD record
ord-043866319e3742d885ff7cb7945a9597
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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