HCID 67778300, compound → HCID 67778377, compound

HRID 1026272Notes

Reaction equation

HRID 1026272 reaction equation
[C:1]([NH:4][C@@H:5]([CH3:16])[CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([OH:15])=O)[O:10][N:9]=1)(=[O:3])[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]2[CH2:28][CH2:27]2)=[CH:20][C:19]=1[S:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH:36]([CH2:41][CH3:42])[CH2:37][CH2:38][CH2:39][CH3:40])=[O:33]>>[C:1]([NH:4][C@@H:5]([CH3:16])[CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]3[CH2:27][CH2:28]3)=[CH:20][C:19]=2[S:29][CH2:30][CH2:31][C:32]([O:34][CH2:35][CH:36]([CH2:41][CH3:42])[CH2:37][CH2:38][CH2:39][CH3:40])=[O:33])=[O:15])[O:10][N:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 67778300HCID 67778300, compoundHCID 67778438HCID 67778438, compound

Product 1

HCID 67778377HCID 67778377, compound

Procedure

Using 3-{[(2S)-2-(acetylamino)propyl]oxy}isoxazole-5-carboxylic acid and 2-ethylhexyl 3-{[2-amino-5-(cyclopropylmethoxy)phenyl]sulfanyl}propanoate, and in the same manner as in Example 2, step C, the title compound was obtained.

Sources & evidence

ORD record
ord-6297a704857c4135b1d24a2e818bdbb6
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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