Pyridine → 1-[(1S)-2-({5-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]-4-methylisoxazol-3-yl}oxy)-1-methylethyl]-3-methylurea

HRID 1026283Notes

Reaction equation

HRID 1026283 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[O:13][C:12]([C:14]4[O:18][N:17]=[C:16]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=O)[O:25]C(C)(C)C)[CH3:22])[C:15]=4[CH3:31])=[N:11][C:10]=3[CH:32]=2)[CH2:3][CH2:2]1.[N:33]1C=CC=C[CH:34]=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[O:13][C:12]([C:14]4[O:18][N:17]=[C:16]([O:19][CH2:20][C@@H:21]([NH:23][C:24]([NH:33][CH3:34])=[O:25])[CH3:22])[C:15]=4[CH3:31])=[N:11][C:10]=3[CH:32]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1049PyridineHCID 86666270tert-butyl [(1S)-2-({5-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]-4-methylisoxazol-3-yl}oxy)-1-methylethyl]carbamate

Product 1

HCID 677783251-[(1S)-2-({5-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]-4-methylisoxazol-3-yl}oxy)-1-methylethyl]-3-methylurea

Procedure

Using tert-butyl [(1S)-2-({5-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]-4-methylisoxazol-3-yl}oxy)-1-methylethyl]carbamate, and in the same manner as in Example 16 (using pyridine instead of triethylamine), the title compound was obtained.

Sources & evidence

ORD record
ord-ce9e736594c84eeb99cb705bbe4f45d9
Source dataset
uspto-grants-2014_05
Patent number
US08729102B2

Reaction notes

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