Tetrabutylammonium Fluoride → HCID 67777804, compound

Participants

Reaction Steps

To a solution of 7-chloro-6-(cyclopropylmethoxy)-2-(4-{[tris(1-methylethyl)silyl]oxy}phenyl)-2H-indazole (112 mg) in THF (1 mL) was added a THF solution (1.0 M, 0.71 mL) of tetrabutylammonium fluoride at room temperature, and the mixture was stirred for 1 hr. The solvent was evaporated under reduced pressure, water was added to the residue, and the mixture was extracted with ethyl acetate. The separated aqueous layer was extracted again with ethyl acetate. The combined organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound as colorless crystals (44.6 mg).

Provenance & Evidence