5-Bromo-2-nitropyridine → HCID 86683703, compound

HRID 1026393Notes

Reaction equation

HRID 1026393 reaction equation
Cl[N:2]1[C@@H:7]([CH3:8])[CH2:6][N:5]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[C@H:4]([CH3:16])[CH2:3]1.Br[C:18]1[CH:19]=[CH:20][C:21]([N+:24]([O-:26])=[O:25])=[N:22][CH:23]=1>>[C:12]([O:11][C:9]([N:5]1[CH2:6][C@H:7]([CH3:8])[N:2]([C:18]2[CH:23]=[N:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=2)[CH2:3][C@H:4]1[CH3:16])=[O:10])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 8176205-Bromo-2-nitropyridineHCID 86683704(2R,5S)-tert-butyl 4-chloro-2,5-dimethylpiperazine-1-carboxylate

Product 1

HCID 86683703HCID 86683703, compoundYield 75%

Procedure

Following the procedures as described for compound 108a, (2R,5S)-tert-butyl 4-chloro-2,5-dimethylpiperazine-1-carboxylate (1.5 g, 6.0 mmol) and 5-bromo-2-nitropyridine (1212 mg, 6.0 mol) were reacted to give 104a as a yellow solid (1500 mg, 75%). LCMS: [M+H]+ 337. See FIG. 4.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-62e9efce9a6747b79ca5fd3bca28e1c9
Source dataset
uspto-grants-2014_05
Patent number
US08729072B2

Reaction notes

Loading…