HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl Acetate → HCID 86683710, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-4-fluoro-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl Acetate | HCID 58044205 | — |
| Reactant | HCID 86683711 | HCID 86683711 | — |
| Product | HCID 86683710 | HCID 86683710 | 59% |
Reaction Steps
Following the procedures as described for compound 108f, reaction of 4-fluoro-2-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate (74 mg) and 107e (60 mg) gave 107f as a yellow solid (60 mg, 59%). LCMS: [M+H]+ 668
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729072B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-24bf4533fefa4b7095b1c606f6313489 |
| Source note | uspto-grants-2014_05 |