Trifluoroacetic acid → HCID 68006072, compound

Participants

Reaction Steps

A trifluoroacetic acid solution (70 ml) of tert-butyl 4-[(2-{[1-(tert-butoxycarbonyl)cyclopropyl]oxy}-5-chloropyridin-3-yl)amino]piperidine-1-carboxylate (7.09 g) was stirred at 70° C. for 28 hours. The temperature was brought back to room temperature, followed by concentration under reduced pressure, and toluene was further added and concentrated under reduced pressure. After ether was added to the residue, the suspension was stirred for 2 hours, and then the insolubles were collected by filtration to afford 7′-chloro-1′-piperidin-4-ylspiro[cyclopropane-1,3′-pyrido[2,3-b][1,4]oxazine]-2′(1′H)-one trifluoroacetate (5.37 g).

Provenance & Evidence