5-Fluoro-2-hydroxyphenylboronic acid → HCID 68006091, compound

HRID 1026573Notes

Reaction equation

HRID 1026573 reaction equation
Br[C:2]1[CH:17]=[CH:16][C:5]([C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:7])=[C:4]([CH3:18])[CH:3]=1.[F:19][C:20]1[CH:21]=[CH:22][C:23]([OH:29])=[C:24](B(O)O)[CH:25]=1>>[F:19][C:20]1[CH:25]=[CH:24][C:23]([OH:29])=[C:22]([C:2]2[CH:17]=[CH:16][C:5]([C:6]([O:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[O:7])=[C:4]([CH3:18])[CH:3]=2)[CH:21]=1

Participants

3

Reactant 2

HCID 37724765-Fluoro-2-hydroxyphenylboronic acidHCID 22568915Benzyl 4-bromo-2-methylbenzoate

Product 1

HCID 68006091HCID 68006091, compound

Procedure

In accordance with the method of Example 1-3, the compound of Example 15-1 was used instead of the compound of Example 1-2, and 5-fluoro-2-hydroxyphenylboronic acid was used instead of 2-hydroxyphenylboronic acid to afford benzyl 5′-fluoro-2′-hydroxy-3-methylbiphenyl-4-carboxylate.

Sources & evidence

ORD record
ord-1b4a919aab864059a58b53323d9a8fee
Source dataset
uspto-grants-2014_05
Patent number
US08729095B2

Reaction notes

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