2-(3-Bromopropoxy)tetrahydro-2H-pyran → HCID 68006264, compound

HRID 1026582Notes

Reaction equation

HRID 1026582 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][O:7]1.[F:12][C:13]1[CH:14]=[C:15]([C:29]2[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=2[OH:36])[CH:16]=[CH:17][C:18]=1[C:19]([O:21]CC1C=CC=CC=1)=[O:20]>>[F:12][C:13]1[CH:14]=[C:15]([C:29]2[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=2[O:36][CH2:2][CH2:3][CH2:4][O:5][CH:6]2[CH2:11][CH2:10][CH2:9][CH2:8][O:7]2)[CH:16]=[CH:17][C:18]=1[C:19]([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 27779882-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 68006353HCID 68006353, compound

Product 1

HCID 68006264HCID 68006264, compound

Procedure

In accordance with the methods of Examples 11-2 and 1-5, 2-(3-bromopropoxy)tetrahydro-2H-pyran was used instead of the compound of Example 11-1, and the compound of Example 13-1 was used instead of the compound of Example 1-3 to afford 3,5′-difluoro-2′-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]biphenyl-4-carboxylic acid.

Sources & evidence

ORD record
ord-fa9d1bf8b1784ef4a7923e84d05a235c
Source dataset
uspto-grants-2014_05
Patent number
US08729095B2

Reaction notes

Loading…