HCID 68006197, compound → HCID 68006112, compound

HRID 1026586Notes

Reaction equation

HRID 1026586 reaction equation
[F:1][C:2]1[C:3]([C:15]([O:17][CH3:18])=[O:16])=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[OH:14])[CH:7]=1.[Si:19]([O:36][CH2:37][CH2:38][C@@H:39](O)[CH2:40][CH3:41])([C:32]([CH3:35])([CH3:34])[CH3:33])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[Si:19]([O:36][CH2:37][CH2:38][C@H:39]([O:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[C:6]1[CH:7]=[C:2]([F:1])[C:3]([C:15]([O:17][CH3:18])=[O:16])=[N:4][CH:5]=1)[CH2:40][CH3:41])([C:32]([CH3:33])([CH3:34])[CH3:35])([C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 68006197HCID 68006197, compoundHCID 68006272HCID 68006272, compound

Product 1

HCID 68006112HCID 68006112, compound

Procedure

In accordance with the method of Example 5-2, the compound of Example 38-2 was used instead of the compound of Example 1-3, and (3S)-1-{[tert-butyl(diphenyl)silyl]oxy}pentane-3-ol (Tetrahedron Letters, 2006, 47(7), 1213-1215) was used instead of the compound of Example 5-1 to afford methyl 5-(2-{[(1R)-3-{[tert-butyl(diphenyl)silyl]oxy}-1-ethylpropyl]oxy}phenyl)-3-fluoropyridine-2-carboxylate.

Sources & evidence

ORD record
ord-5ef34f1a93874b9fa0e54db722384e80
Source dataset
uspto-grants-2014_05
Patent number
US08729095B2

Reaction notes

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