Citric Acid → HCID 68006010, compound

Participants

Reaction Steps

To a tetrahydrofuran solution (7.0 ml) of methyl 5-(2-{[(1R)-3-{[tert-butyl(diphenyl)silyl]oxy}-1-ethylpropyl]oxy}phenyl)-3-fluoropyridine-2-carboxylate (440 mg) was added at room temperature 1 N aqueous sodium hydroxide solution (1.69 ml), followed by stirring for 2 hours. The reaction solution was poured into a 10% aqueous citric acid solution, and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 5-(2-{[(1R)-3-{[tert-butyl(diphenyl)silyl]oxy}-1-ethylpropyl]oxy}phenyl)-3-fluoropyridine-2-carboxylic acid (429 mg).

Provenance & Evidence