Citric Acid → HCID 68006137, compound

Participants

Reaction Steps

To a tetrahydrofuran solution (20.0 ml) of methyl 2′-{[(1R)-3-hydroxy-1-methylpropyl]oxy}-3-nitrobiphenyl-4-carboxylate (793 mg) was added at room temperature potassium trimethylsilanolate (982 mg), followed by stirring for 7 hours. A 10% aqueous citric acid solution was added to the reaction solution, and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 2′-{[(1R)-3-hydroxy-1-methylpropyl]oxy}-3-nitrobiphenyl-4-carboxylic acid (761 mg).

Provenance & Evidence