Acetate → 1-(1H-indol-5-yl)-3-methyl-pyrazole-4-carboxylic acid ethyl ester

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Reaction Steps

3-Methyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.43 g, 9.27 mmol) and 1H-indol-5-ylboronic acid (1.50 g, 9.29 mmol) were dissolved in N,N-dimethylformamide (93 mL). Cupper (II) acetate (1.27 g, 6.98 mmol) and pyridine (1.50 mL, 18.5 mmol) were added, and the mixture was stirred for 3 days at room temperature. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography to give the title compound (1.2433 g, 4.62 mmol, 50% Yield).

Provenance & Evidence