5-Indolylboronic acid → HCID 57963770, compound

HRID 1026612Notes

Reaction equation

HRID 1026612 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6](B(O)O)=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH2:13]([O:15][C:16]([C:18]1[C:19]([C:23]([F:26])([F:25])[F:24])=[N:20][NH:21][CH:22]=1)=[O:17])[CH3:14]>>[CH2:13]([O:15][C:16]([C:18]1[C:19]([C:23]([F:25])([F:26])[F:24])=[N:20][N:21]([C:6]2[CH:5]=[C:4]3[C:9](=[CH:8][CH:7]=2)[NH:1][CH:2]=[CH:3]3)[CH:22]=1)=[O:17])[CH3:14]

Participants

3

Reactant 2

HCID 27343615-Indolylboronic acidHCID 178469923HCID 178469923, compound

Product 1

HCID 57963770HCID 57963770, compoundYield 72.1%

Procedure

1H-indol-5-ylboronic acid (1,000 mg, 6.21 mmol) and 3-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester (646 mg, 3.10 mmol) were reacted according to the same procedure as Preparation 1 to give the title compound (723 mg, 72% Yield).

Workup

  1. customaccording to the same procedure as Preparation 1

Sources & evidence

ORD record
ord-6138854cc09543c78a8fd69607726e6e
Source dataset
uspto-grants-2014_05
Patent number
US08729273B2

Reaction notes

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