Ethyl cyanoacetate → HCID 67107921, compound

Participants

Reaction Steps

A mixture of ethylcyanoacetate (1.0 g, 7.75 mmol) and t-butoxy bis(dimethylamino)methane (2.7 g, 15.5 mmol) was stirred for 18 h at room temperature. After distillation under reduced pressure, 5-aminoindole (1.3 g, 7.75 mmol) was added. The mixture was dissolved in n-butanol, and refluxed for 15 h. The reaction solution was cooled, ethyl acetate was added thereto, and washed with aqueous sodium bicarbonate solution. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting solid was filtered, washed with ethyl acetate and dried to give the title compound (0.33 g, 17% Yield).

Provenance & Evidence