N-benzyl-3-chloro-N-(2-methylallyl)-1,2-dihydrocyclobutabenzene-1-carboxamide → trans-2-benzyl-6-chloro-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-1-one

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Reaction Steps

A solution of N-benzyl-3-chloro-N-(2-methylallyl)-1,2-dihydrocyclobutabenzene-1-carboxamide (5.52 mmol, 1.8 g) in bromobenzene (21 ml) was irradiated in a microwave for 30 min at 210 degrees. The bromobenzene was removed under reduced pressure and then purified by flash chromatographed using ethyl acetate in heptane (10 to 20%) to afford trans-2-benzyl-6-chloro-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-1-one (221 mg, 12% yield), followed by cis-2-benzyl-6-chloro-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindol-1-one (649 mg, 36% yield).

Provenance & Evidence