HCID 70665177, compound → HCID 70664739, compound

Participants

Reaction Steps

A suspension of cis-2-benzyl-6-chloro-3a-methyl-7-(prop-1-en-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole (0.156 mmol, 55 mg) and 5% Pd—C (7.81 μmol, 16.63 mg) in MeOH (3 ml) was stirred under H2 atmosphere (1 bar, multiple hydrogenator) at ° C. for 1.5 h and then passed through Whatman membrane filter. The resulting filtrate was concentrated in vacuo a crude solid that was redissolved in MeOH (3 ml) and further 5% Pd—C (7.81 μmol, 16.63 mg) was added. The resulting suspension was stirred under H2 atmosphere (balloon) at 20° C. for 3 h and then passed through Whatman membrane. The filtrate was concentrated to give cis-2-benzyl-6-chloro-7-isopropyl-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole (46.6 mg), m/z=354.2 [M+H]+.

Provenance & Evidence