HCID 70664461, compound → HCID 70664607, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of trans-2-benzyl-6-chloro-3a-methyl-7-vinyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole (0.095 mmol, 32 mg) and 5% Pd—C (4.74 μmol, 10.08 mg) in MeOH (3 ml) was stirred under H2 atmosphere (1 bar, multiple hydrogenator) at 20° C. for 1.5 h. The suspension was then passed through a Whatman membrane filter and the resulting filtrate was concentrated in vacuo to afford trans-2-benzyl-6-chloro-7-ethyl-3a-methyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]isoindole (24.9 mg), m/z=340.2 [M+H]+.

Provenance & Evidence