(Diethylamino)sulfur trifluoride → HCID 11153350, compound

Participants

Reaction Steps

The title compound was prepared by reacting (S)—N-{3-[4-(4-fluoro-4-hydroxymethylpiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.0 mmol) with DAST (1.25 mmol) in diglyme (10 ml) at a temperature 0° C. for two hours and by purifying the compound by silica gel column chromatography in 24% yield.

Provenance & Evidence