Sodium Cyanide → HCID 11752559, compound

HRID 1026696Notes

Reaction equation

HRID 1026696 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:15]2[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]2=[O:25])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1.[C-:26]#[N:27].[Na+].[CH3:29][O:30][C:31]([C:33]1[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=1)=[O:32]>>[CH3:29][O:30][C:31]([C:33]1[CH:39]=[CH:38][C:36]([NH:37][C:11]2([C:26]#[N:27])[CH2:10][CH2:9][N:8]([C:7]3[CH:6]=[CH:5][C:4]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:3][C:2]=3[F:1])[CH2:13][CH2:12]2)=[CH:35][CH:34]=1)=[O:32]

Participants

4

Reactant 3

HCID 8929Sodium CyanideHCID 12082Methyl 4-aminobenzoateHCID 54375226N-[(5S)-3-[3-fluoro-4-(4-oxopiperidinyl)phenyl]-2-oxo-5-oxazolidinyl]methylacetamide

Product 1

HCID 11752559HCID 11752559, compoundYield 44%

Procedure

By using procedure as described in Example 45 and by reacting (S)—N-{3-[3-fluoro-4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide with sodium cyanide and 4-methoxycarbonylaniline the compound was obtained in 44% yield.

Workup

  1. customwas obtained in 44% yield

Sources & evidence

ORD record
ord-3b5e372327c44fbca5a4d477cb06a396
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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