2-Methoxyaniline → HCID 11409611, compound

HRID 1026700Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([N:17]2[CH2:21][C@H:20]([CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:19][C:18]2=[O:27])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][C:11](=O)[C:10]([CH3:16])([CH3:15])[CH2:9]1.[C-:28]#[N:29].[Na+].[CH3:31][O:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH2:35]>>[CH3:31][O:32][C:33]1[CH:39]=[CH:38][CH:37]=[CH:36][C:34]=1[NH:35][C:11]1([C:28]#[N:29])[CH2:12][CH2:13][N:8]([C:7]2[CH:6]=[CH:5][C:4]([N:17]3[CH2:21][C@H:20]([CH2:22][NH:23][C:24](=[O:26])[CH3:25])[O:19][C:18]3=[O:27])=[CH:3][C:2]=2[F:1])[CH2:9][C:10]1([CH3:16])[CH3:15]

Participants

Reactant 3

HCID 70002-Methoxyaniline

HCID 8929Sodium Cyanide

HCID 59754027HCID 59754027, compound

Product 1

HCID 11409611HCID 11409611, compoundYield 64%

Procedure

By using procedure as described in Example 45 and by reacting (S)—N-{3-[3-fluoro-4-(4-oxo-3,3-dimethylpiperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide with sodium cyanide and 2-methoxyaniline the compound was obtained in 64% yield.

Workup

customwas obtained in 64% yield

Sources & evidence

ORD record: ord-6f1acb0435bc4e8cafa614b41e9a68fa
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729269B2

Reaction notes

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