Lawesson's reagent → HCID 86599013, compound

HRID 1026704Notes

Reaction equation

HRID 1026704 reaction equation
[CH2:1]([O:3][C:4]([NH:6][CH:7]([C:10]1([C:34]#[N:35])[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][C@H:25]([CH2:27][NH:28][C:29](=O)[CH3:30])[O:24][C:23]3=[O:32])=[CH:18][C:17]=2[F:33])[CH2:12][CH2:11]1)[C:8]#[N:9])=[O:5])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:45])=CC=1>>[CH2:1]([O:3][C:4]([NH:6][CH:7]([C:10]1([C:34]#[N:35])[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][C@H:25]([CH2:27][NH:28][C:29](=[S:45])[CH3:30])[O:24][C:23]3=[O:32])=[CH:18][C:17]=2[F:33])[CH2:12][CH2:11]1)[C:8]#[N:9])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 68700676HCID 68700676, compound

Product 1

HCID 86599013HCID 86599013, compoundYield 58%

Procedure

By using procedure as described in Example 82 and by reacting (S)—N-{3-[4-(4-(1-ethoxycarbonylamino-1-cyanomethyl)-4-cyanopiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide and Lawesson's reagent the compound was obtained in 58% yield.

Workup

  1. customwas obtained in 58% yield

Sources & evidence

ORD record
ord-0c08ba249a1247a88cb6de4b8c36130f
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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