Lawesson's reagent → HCID 11213526, compound

HRID 1026705Notes

Reaction equation

HRID 1026705 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]2([C:32]#[N:33])[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=O)[CH3:28])[O:22][C:21]4=[O:30])=[CH:16][C:15]=3[F:31])[CH2:10][CH2:9]2)[CH:2]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:43])=CC=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]2([C:32]#[N:33])[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([N:20]4[CH2:24][C@H:23]([CH2:25][NH:26][C:27](=[S:43])[CH3:28])[O:22][C:21]4=[O:30])=[CH:16][C:15]=3[F:31])[CH2:10][CH2:9]2)[CH:2]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 11385445HCID 11385445, compound

Product 1

HCID 11213526HCID 11213526, compoundYield 58%

Procedure

By using procedure as described in Example 82 and by reacting (S)—N-{3-[4-(4-(pyridin-3-ylamino)-4-cyanopiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide and Lawesson's reagent the compound was obtained in 58% yield.

Workup

  1. customwas obtained in 58% yield

Sources & evidence

ORD record
ord-719c4454cc36440eaf032bb0fb9cbe97
Source dataset
uspto-grants-2014_05
Patent number
US08729269B2

Reaction notes

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