HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → HCID 60133454, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Boron trifluoride | HCID 6356 | — |
| Reactant | N-[(5S)-3-[3-fluoro-4-(4-oxopiperidinyl)phenyl]-2-oxo-5-oxazolidinyl]methylacetamide | HCID 54375226 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 60133454 | HCID 60133454 | 78% |
Reaction Steps
The title compound was prepared by reacting (S)—N-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.0 mmol), 2-aminoethanol (1.0 mmol) and BF3. etherate (2.0 mmol) in tetrahydrofuran (10 ml) at a temperature 65° C. for 6 hours in 78% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729269B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-1a86b1ca07bc4febb586883a93479cfd |
| Source note | uspto-grants-2014_05 |