HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026751Generated: October 29, 2026
Cesium carbonate → ethyl 1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate
https://huagongshe.com/reaction/1026751
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | ethyl 1H-pyrazole-4-carboxylate | HCID 142179 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Reactant | 1-Iodo-4-(trifluoromethoxy)benzene | HCID 2777294 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | ethyl 1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate | HCID 44818853 | 9.6% |
Reaction Steps
A solution of ethyl 4-pyrazolecarboxylate (500 mg), 4-(trifluoromethoxy)iodobenzene (1.00 g), trans-1,2-bis(methylamino)cyclohexane (100 mg), copper iodide (70 mg) and cesium carbonate (1.7 g) in dioxane (5.0 mL) was stirred while heating at 100° C. for 5 hr. The reaction mixture was filtered through Celite and the solvent was then distilled off under reduced pressure. The resulting residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=98:2-80:20) to afford ethyl 1-[4-(trifluoromethoxy)phenyl]-1H-pyrazole-4-carboxylate (100 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08729271B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-dcfc75416d304d979c185c5d78ac54a8 |
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| Source note | uspto-grants-2014_05 |
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