反应详情

A suspension of 320 (0.65 g, 1.3 mmol) in 5:2:1 acetone/water/TFA (100 mL) was heated to reflux for 6 h. The mixture was then cooled and concentrated. The resulting solid residue was suspended in water, isolated by suction filtration, washed with ethyl acetate and dried in vacuo yielding 321 (0.49 g, 1.1 mmol, 85% yield) which was used without further purification in the next step. MS: 449.0 (M+H).

1. temperaturewas heated
2. temperatureto reflux for 6 h
3. temperatureThe mixture was then cooled
4. concentrationconcentrated
5. customisolated by suction filtration
6. washwashed with ethyl acetate
7. customdried in vacuo