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HRID 1026862作成日：2026年10月25日
Trifluoroacetic acid → (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-aminoethyl)-N-methyldocosa-4,7,10,13,16,19-hexaenamide
https://huagongshe.com/reaction/1026862
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | HCID 86639146 | HCID 86639146 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-aminoethyl)-N-methyldocosa-4,7,10,13,16,19-hexaenamide | HCID 59193341 | 97.3% |
反応手順
To a solution of tert-butyl 2-((4Z,7Z,10Z,13Z,16Z,19Z)—N-methyldocosa-4,7,10,13,16,19-hexaenamido)ethylcarbamate (1.71 g, 3.5 mmol)) in dichloromethane (50 mL) at 0° C. was slowly added TFA (17 mL). The mixture was stirred (0° C., 2 h,) basified to pH 10 with saturated aqueous Na2CO3 and extracted with EA (3×150 mL). The combined organic layers were dried over MgSO4 and concentrated under reduced pressure to afford (4Z,7Z,10Z,13Z,16Z,19Z)—N-(2-aminoethyl)-N-methyldocosa-4,7,10,13,16,19-hexaenamide (1.31 g, 97%) as a light yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08729293B2 |
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| 出典データセット | uspto-grants-2014_05 |
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| ORD ID | ord-c155068c83da46188246bf494bf2d742 |
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| 出典メモ | uspto-grants-2014_05 |
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