反应详情

温度

60 °C

Ethyl 3-bromo-7-hydroxypyrazolo[1,5-a]pyrimidine-6-carboxylate (Journal of Medicinal Chemistry, vol. 25, p. 235, 1982) (11.0 g, 38.5 mmol) was dissolved in ethanol (134 mL), 2 mol/L aqueous sodium hydroxide solution (134 mL, 269 mmol) was added, and the mixture was stirred at 60° C. for 1 hr. The reaction mixture was cooled to room temperature, and ethanol was evaporated under reduced pressure. 2 mol/L Hydrochloric acid (140 mL) was added under ice-cooling, and the mixture was stirred at room temperature for 30 min. The precipitate was collected by filtration, and washed with water (100 mL) and 2-propanol (50 mL) to give the title compound (9.9 g, 99%).

1. temperatureThe reaction mixture was cooled to room temperature
2. customethanol was evaporated under reduced pressure
3. addition2 mol/L Hydrochloric acid (140 mL) was added under ice-
4. temperaturecooling
5. stirringthe mixture was stirred at room temperature for 30 min
6. filtrationThe precipitate was collected by filtration
7. washwashed with water (100 mL) and 2-propanol (50 mL)