HRID1026895

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID73702

Ethanesulfonamide

C2H7NO2S

结构：O=C(O)c1cnn2c(NCc3cccc(F)c3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12

HCID67540477

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)NC(=O)c1cnn2c(NCc3cccc(F)c3)c(C(=O)N3CCC(c4ccccc4)CC3)cnc12

HCID67540479

未命名化合物

PROCEDURE

实验过程

In the same manner as in Example 1, step 6 and using 7-(3-fluorobenzylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.09 g, 0.18 mmol) obtained in Example 6, step 2 and ethanesulfonamide (0.11 g, 1.08 mmol) instead of methanesulfonamide, compound a-7 (0.04 g, 38%) was obtained.

WORKUP

后处理

customcompound a-7 (0.04 g, 38%) was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-140fa15f59444a5b91cf69de58a93175
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729264B2
来源说明: uspto-grants-2014_05

反应 SMILES

[F:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]1[N:12]2[N:13]=[CH:14][C:15]([C:16](O)=[O:17])=[C:11]2[N:10]=[CH:9][C:8]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:23][CH2:22]1)=[O:20].[CH2:36]([S:38]([NH2:41])(=[O:40])=[O:39])[CH3:37]>>[F:1][C:2]1[CH:3]=[C:4]([CH:33]=[CH:34][CH:35]=1)[CH2:5][NH:6][C:7]1[N:12]2[N:13]=[CH:14][C:15]([C:16]([NH:41][S:38]([CH2:36][CH3:37])(=[O:40])=[O:39])=[O:17])=[C:11]2[N:10]=[CH:9][C:8]=1[C:19]([N:21]1[CH2:26][CH2:25][CH:24]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:23][CH2:22]1)=[O:20]