Methanesulfonamide → HCID 67541255, compound

HRID 1026896Notes

Reaction equation

[CH:1]1([CH2:7][NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18](O)=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][CH:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)=[O:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:35][S:36]([NH2:39])(=[O:38])=[O:37]>>[CH:1]1([CH2:7][NH:8][C:9]2[N:14]3[N:15]=[CH:16][C:17]([C:18]([NH:39][S:36]([CH3:35])(=[O:38])=[O:37])=[O:19])=[C:13]3[N:12]=[CH:11][C:10]=2[C:21]([N:23]2[CH2:28][CH2:27][CH:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:25][CH2:24]2)=[O:22])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67539533HCID 67539533, compound

Product 1

HCID 67541255HCID 67541255, compound

Procedure

In the same manner as in Example 1, step 6 and using 7-cyclohexylmethylamino-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.08 g, 0.17 mmol) obtained in step 2 and methanesulfonamide (0.11 g, 0.87 mmol), compound a-8 (80 mg, 32%) was obtained.

Workup

customcompound a-8 (80 mg, 32%) was obtained

Sources & evidence

ORD record: ord-4ab8f5d1608744c08409fea7136641d0
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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