Methanesulfonamide → HCID 67541016, compound

HRID 1026897Notes

Reaction equation

[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([C:15]3[CH:16]=[N:17][C:18]4[N:19]([N:29]=[CH:30][C:31]=4[C:32](O)=[O:33])[C:20]=3[NH:21][CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:35][S:36]([NH2:39])(=[O:38])=[O:37]>>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:13]([C:15]3[CH:16]=[N:17][C:18]4[N:19]([N:29]=[CH:30][C:31]=4[C:32]([NH:39][S:36]([CH3:35])(=[O:38])=[O:37])=[O:33])[C:20]=3[NH:21][CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[O:14])[CH2:11][CH2:12]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67540680HCID 67540680, compound

Product 1

HCID 67541016HCID 67541016, compound

Procedure

In the same manner as in Example 1, step 6 and using 6-(4-phenylpiperidine-1-carbonyl)-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.05 g, 0.11 mmol) obtained in step 2 and methanesulfonamide (0.052 g, 0.550 mmol), compound a-9 (0.03 g, 58%) was obtained.

Workup

customcompound a-9 (0.03 g, 58%) was obtained

Sources & evidence

ORD record: ord-3ed6c3e78e2640e2a440b8e94d3c8a45
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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