Methanesulfonamide → HCID 67540007, compound

HRID 1026899Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][CH:36]=1)[CH2:6][NH:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17](O)=[O:18])=[C:12]2[N:11]=[CH:10][C:9]=1[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:24][CH2:23]1)=[O:21].[CH3:37][S:38]([NH2:41])(=[O:40])=[O:39]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][CH:36]=1)[CH2:6][NH:7][C:8]1[N:13]2[N:14]=[CH:15][C:16]([C:17]([NH:41][S:38]([CH3:37])(=[O:40])=[O:39])=[O:18])=[C:12]2[N:11]=[CH:10][C:9]=1[C:20]([N:22]1[CH2:27][CH2:26][CH:25]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH2:24][CH2:23]1)=[O:21]

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 67540626HCID 67540626, compound

Product 1

HCID 67540007HCID 67540007, compoundYield 88.9%

Procedure

In the same manner as in Example 1, step 6 and using 7-(3-methoxybenzylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (0.06 g, 0.12 mmol) obtained in step 2 and methanesulfonamide (0.06 g, 0.62 mmol), the title compound (0.06 g, 69%) was obtained.

Sources & evidence

ORD record: ord-4425c3e7094848258c48247540d7232f
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729264B2

Reaction notes

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